Vitamin B-6 Restriction Reduces the Production of Hydrogen Sulfide and its Biomarkers by the Transsulfuration Pathway in Cultured Human Hepatoma Cells

摘要

Background: Pyridoxal 5′-phosphate (PLP) functions as a coenzyme in many cellular processes including one-carbon metabolism and the interconversion and catabolism of amino acids. PLP-dependent enzymes, cystathionine β-synthase and cystathionine γ-lyase, function in transsulfuration but also have been implicated in the production of the endogenous gaseous signaling molecule hydrogen sulfide (H2S) concurrent with the formation of the biomarkers lanthionine and homolanthionine.