Elevated levels of serum antibodies against alpha-1, 6-glucan in patients with systemic lupus erythematosus or rheumatoid arthritis

摘要

This study was undertaken to investigate whether levels of anti-alpha-1, 6-glucan antibodies in human sera correlate with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Serum samples were collected from patients with SLE ( n = 30), RA ( n = 30) and healthy adult volunteers. IgG , IgA and IgM levels against alpha-1, 6-glucan were measured using enzyme linked immunosorbent assays. Anti -alpha-1, 6-glucan IgG prevalence was raised in patients with active SLE (73.3%) and RA (60%) compared with healthy controls (13.3%). Strong correlation between anti-alpha-1,6-glucan- IgG levels and anti-perinuclear factor ( r = 0.642; p r = 0.675; p IgA or- IgM levels were noted between different groups. We conclude that anti-alpha-1,6-glucan- IgG levels were significantly elevated in patients with SLE or RA and positively correlated with disease activity.