Ameliorative effects of physcion 8- O - β -glucopyranoside isolated from Polygonum cuspidatum on learning and memory in dementia rats induced by A β _1–40

摘要

Context: Polygonum cuspidatum Sieb. Et Zucc. (Polygonaceae) has been traditionally used in folk medicine to treat various diseases. Objective: This study investigates the ameliorative effects of physcion 8-O-β-glucopyranoside (PSG) isolated from P. cuspidatum on learning and memory in dementia rats induced by Aβ_1–40. Materials and methods: Dementia rats were prepared by intracerebroventricular injection of Aβ_1–40. PSG (5, 10, 20, and 40?mg/kg/d, for 5?d) was administered orally. Ameliorative activity of PSG in dementia rats was evaluated by the Morris water maze (MWM) test, and its mechanisms were explored by evaluating AchE activity, levels of DA, NE, and 5-HT in hippocampus, and drebrin protein expressions in hippocampus. Results: Our results indicated that PSG (5, 10, 20, and 40?mg/kg/d) significantly inhibited the prolonged latency in dementia rats (p?p?p?p?p?p?p?Conclusions: PSG can significantly enhance learning and memory in Aβ_1–40-induced dementia rats, and the mechanisms may be related to increase levels of Ach, 5-HT, NE, and DA, decrease Aβ contents, and up-regulation of drebrin proteins in hippocampus.