Present review aimed to provide a comprehensive documentation of plants used as anti-rheumatic ethnomedicines inPakistan and to suggest future recommendations. Data on anti-rheumatic plants was collected from published scientificpapers, reports and thesis using online searching engines such as Google Scholar PubMed and Science Direct. Five distinctzones in the country were classified on the basis of geography, humidity and rainfall. We used Sorenson similarity index forplants and their parts used between different zones. A total of 137 anti-rheumatic plant species representing 55 families and104 genera are used in Pakistan. Herbs (87 plants) were the primary source of anti-rheumatic medicinal plants, while leaves(22 % plant species) were the most frequently used part in the preparation of ethnomedicinal recipes. Highest number of 52medicinal plant species were found in Zone A having high mountains and cold climate where the prevalence of rheumatismwas more common. Solanum surattense was found with highest conservation concerns as it was using in 13 different areasagainst rheumatism. Results of Sorenson index revealed that there is a similarity of plants and its parts uses betweendifferent zones. In conclusions, geography and climate have an important role in causing rheumatic disease. Pakistan has anumber of anti-rheumatic plants that are used by the local populations through their traditional knowledge. Moreover, interzonal similarities among plants and its part uses indicate higher pharmacological potency of these medicinal plants. Further,the review will also provide an insight regarding the conservation status of reported plants.
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