首页> 外文期刊>Signal transduction and targeted therapy. >The potent roles of salt-inducible kinases (SIKs) in metabolic homeostasis and tumorigenesis
【24h】

The potent roles of salt-inducible kinases (SIKs) in metabolic homeostasis and tumorigenesis

机译:盐诱导激酶(SIK)在代谢稳态和肿瘤发生中的效力作用

获取原文
       

摘要

Salt-inducible kinases (SIKs) belong to AMP-activated protein kinase (AMPK) family, and functions mainly involve in regulating energy response-related physiological processes, such as gluconeogenesis and lipid metabolism. However, compared with another well-established energy-response kinase AMPK, SIK roles in human diseases, especially in diabetes and tumorigenesis, are rarely investigated. Recently, the pilot roles of SIKs in tumorigenesis have begun to attract more attention due to the finding that the tumor suppressor role of LKB1 in non-small-cell lung cancers (NSCLCs) is unexpectedly mediated by the SIK but not AMPK kinases. Thus, here we tend to comprehensively summarize the emerging upstream regulators, downstream substrates, mouse models, clinical relevance, and candidate inhibitors for SIKs, and shed light on SIKs as the potential therapeutic targets for cancer therapies.
机译:盐诱导型激酶(SIK)属于AMP活化蛋白激酶(AMPK)家族,主要涉及调节能源响应相关的生理过程,例如葡糖生成和脂质代谢。然而,与另一种良好的能量 - 反应激酶AMPK相比,人类疾病中的SIK作用,特别是在糖尿病和肿瘤内疾病中,很少研究。最近,由于发现在非小细胞肺癌(NSCLC)中的肿瘤抑制因子(NSCLC)意外介导但不是AMPK激酶的发现,SIK在肿瘤发生中的肿瘤抑制作用的试点已经开始吸引更多的关注。因此,在这里,我们倾向于全面地将新兴的上游调节因子,下游底母,小鼠模型,临床相关性和候选性抑制剂综合地总结为SIK的潜在治疗靶标对癌症疗法的潜在治疗靶标。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号