Gas Transport Characteristics of Hemocorrectors and Perfusates Based on Perfluorocarbon Blood-Substituting Emulsions

摘要

This review summarizes the data regarding the gas transportcharacteristics of hemocorrection and perfusates on the basis oflow concentrated drugs nano-sized perfluorocarbonic 20% Per-ftoran (a blood substitute, it is allowed for clinical use in Russia),20% Ftoremulsion III (an improved blood substitute, registeredin Russia), 10-20% Perfusol (a perfusion solution for perfusion ofthe isolated heart), 20% Ftorem (a cardioplegic emulsion for sur-geries on the stopped heart) used in the biomedical field. The com-pensation of blood loss using traditional plasma substitutes with-out the gas transport function or with low gas transport charac-teristics leads to a decrease in the oxygen capacity of the resultingmixture and subsequently to deterioration in the oxygen transportcharacteristics of blood. The synthetic gas-transport blood substi-tutes can be used in the treatment of various forms of ischemia,such as carbon monoxide poisoning. Furthermore, recent resultsregarding the mechanism of COVID19 infection indicate a possi-ble use of the synthetic gas-transport blood substitutes in the treat-ment and therapy of COVID19 infected patients.