VibrioBase: A Model for Next-Generation Genome and Annotation Database Development

摘要

To facilitate the ongoing research ofVibriospp., a dedicated platform for theVibrioresearch community is needed to host the fast-growing amount of genomic data and facilitate the analysis of these data. We present VibrioBase, a useful resource platform, providing all basic features of a sequence database with the addition of unique analysis tools which could be valuable for theVibrioresearch community. VibrioBase currently houses a total of 252Vibriogenomes developed in a user-friendly manner and useful to enable the analysis of these genomic data, particularly in the field of comparative genomics. Besides general data browsing features, VibrioBase offers analysis tools such as BLAST interfaces and JBrowse genome browser. Other important features of this platform include our newly developed in-house tools, the pairwise genome comparison (PGC) tool, and pathogenomics profiling tool (PathoProT). The PGC tool is useful in the identification and comparative analysis of two genomes, whereas PathoProT is designed for comparative pathogenomics analysis ofVibriostrains. Both of these tools will enable researchers with little experience in bioinformatics to get meaningful information fromVibriogenomes with ease. We have tested the validity and suitability of these tools and features for use in the next-generation database development.