Silk fibroin/hydroxyapatite scaffold: a highly compatible material for bone regeneration

摘要

In recent years remarkable efforts have been made to produce artificial bone through tissueengineering techniques. Silk fibroin (SF) and hydroxyapatite (HA) have been used in bonetissue regeneration as biomaterials due to mechanical properties of SF and biocompatibility ofHA. There has been growing interest in developing SF/HA composites to reduce bone defects.In this regard, several attempts have been made to study the biocompatibility and osteoconductive properties of this material. This article overviews the recent advance from last fewdecades in terms of the preparative methods and application of SF/HA in bone regeneration. Itsfirst part is related to SF that presents the most common sources, preparation methods andcomparison of SF with other biomaterials. The second part illustrates the importance of HA byproviding information about its production and properties. The third part presents comparative studies of SF/HA composites with different concentrations of HA along with methods ofpreparation of composites and their applications.