Acute effects of Amomum villosumLour. fruit extract on postprandial glycemia and insulin secretion: A single-blind, placebo-controlled, crossover study in healthy subjects

摘要

Background Amomum villosum Lour., (Zingiberaceae) an herbaceous plant in the ginger family, has been used to treat various diseases. In a single-blind, randomized, crossover study, we assessed the postprandial blood insulin and blood glucose responses in healthy subjects (n?=?40) after the Amomum villosum water extract (AVE) (5?g/person) or a placebo (5?g/person) consumption. Methods During each treatment course, the healthy subject consumed a regular late afternoon meal, followed by fasting for 12?h, and arrived at the clinical study center the next morning. Blood insulin and blood glucose levels were assessed at 0, 30, 60, 90, and 120?min after AVE consumption. Between each treatment, the subjects accomplished one week of a washout period. Results The AVE intake demonstrated a significant (67.26%) decline in postprandial blood glucose AUCsub0–120 min/sub (incremental area under the curve from 0 to 120?min) versus the placebo ( P =?0.011). Furthermore, AVE reduced postprandial blood insulin AUCsub0–120 min/sub by 59.95% compared to the placebo group ( P ?0.003), supporting the blood glucose results. Conclusion This study revealed that AVE consumption significantly reduced postprandial insulin and glucose levels in healthy individuals, due in part to inhibition of α-glucosidase, and glucose transport.