Recurrent Pregnancy Loss in Patients with Polycystic Ovary Syndrome: A Case Control Study

摘要

>Objectives: style="font-family:;" "=""> style="font-family:Verdana;"> To identify different biophysical and hormonal factors that could contribute to recurrent pregnancy loss in Saudi women who have been diagnosed with polycystic ovary syndrome. style="font-family:Verdana;">Study Design: style="font-family:Verdana;"> Case-control study. style="font-family:Verdana;"> Settings: style="font-family:Verdana;"> Infertility clinic in Dammam Maternity and Children Hospital. style="font-family:Verdana;"> Cases: style="font-family:Verdana;"> PCOS patients with recurrent pregnancy loss. style="font-family:Verdana;">Controls: style="font-family:Verdana;"> PCOS patients without recurrent pregnancy loss. style="font-family:Verdana;">Results: style="font-family:Verdana;"> The prevalence of recurrent abortion in PCOS patients was 31%. There was no significant difference between the cases and the controls in the age, 33.1 years versus 31.9 years, BMI, 31.4 kg/m style="font-family:Verdana;">2 style="font-family:;" "=""> style="font-family:Verdana;">versus 31.6 style="font-family:;" "=""> style="font-family:Verdana;">kg/m style="font-family:Verdana;">2 style="font-family:Verdana;"> respectively. There was no significant difference in the successful pregnancies outcome in cases and controls, term deliveries 84% versus 90%, preterm deliveries 10% versus 5%, twin pregnancy 6% versus 5% respectively. There was no significant difference in the hormonal profile (prolactin, LH, FSH, LH/FSH ratio, TSH, progesterone, testosterone) between cases and controls. Serum estradiol level was significantly lower in the cases compared to the controls, 55.5 pg/mL versus 83.9 pg/mL respectively (p < 0.01). style="font-family:Verdana;">Conclusion: style="font-family:Verdana;"> PCOS patients with recurrent abortions had no significant increase in the age, BMI, preterm pregnancy, multiple gestation and ectopic pregnancy. The hormonal profile (prolactin, LH, FSH, LH/FSH ratio, TSH, progesterone, testosterone) was comparable between the cases and the controls, except for serum estradiol level, which was significantly lower in PCOS patients with recurrent abortions.