TP53 gene mutation is frequent in patients with acute myeloid leukemia and complex karyotype, and is associated with very poor prognosis

D Bowen; M J Groves; A K Burnett; Y Patel; C Allen; C Green; R E Gale; R Hills; D C Linch

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TP53 gene mutation is frequent in patients with acute myeloid leukemia and complex karyotype, and is associated with very poor prognosis

机译：TP53基因突变在急性髓性白血病和复杂的核型患者中经常出现，并且与预后非常差有关

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《Leukemia》 |2009年第1期|共4页
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D Bowen; M J Groves; A K Burnett; Y Patel; C Allen; C Green; R E Gale; R Hills; D C Linch;
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1. Monosomal karyotype routinely defines a poor prognosis subgroup in acute myeloid leukemia and is frequently associated with TP53 deletion [J] . GaillardJ.-B., ChiesaJ., ReboulD., Leukemia and lymphoma . 2012,第2期

机译：染色体核型常规定义为急性髓细胞性白血病预后较差的亚组，并经常与TP53缺失有关
2. Monosomal karyotype routinely defines a poor prognosis subgroup in acute myeloid leukemia and is frequently associated with TP53 deletion [J] . GaillardJ.-B., ChiesaJ., ReboulD., Leukemia and lymphoma . 2012,第1a2期

机译：染色体核型常规定义为急性髓细胞性白血病预后较差的亚组，并经常与TP53缺失有关
3. ASXL1 mutations define a subgroup of patients with acute myeloid leukemia with distinct gene expression profile and poor prognosis: a meta-analysis of 3311 adult patients with acute myeloid leukemia [J] . Shivarov Velizar, Gueorguieva Ralitza, Ivanova Milena, Leukemia and lymphoma . 2015,第6期

机译：ASXL1突变定义了具有明显基因表达谱和预后不良的急性髓细胞性白血病患者亚组：一项对3311例急性髓性白血病成年患者的荟萃分析
4. A BLSTM with Attention Network for Predicting Acute Myeloid Leukemia Patient’s Prognosis using Comprehensive Clinical Parameters [C] . Chih-Chuan Lu, Jeng-Lin Li, Yu-Fen Wang, . 2019

机译：带有注意力网络的BLSTM，可使用综合的临床参数预测急性髓性白血病患者的预后
5. Loss of Egr1 plays a role in murine leukemogenesis and may play a role in the development of acute myeloid leukemia and therapy-related acute myeloid leukemia. [D] . Joslin, John M. 2006

机译：Egr1的丢失在小鼠白血病的发生中起作用，并且可能在急性髓细胞性白血病和与治疗有关的急性髓细胞性白血病的发展中起作用。
6. Monosomal karyotype and chromosome 17p loss or TP53 mutations in decitabine-treated patients with acute myeloid leukemia [O] . Heiko Becker, Dietmar Pfeifer, Gabriele Ihorst, -1

机译：地西他滨治疗的急性髓性白血病患者的染色体核型和染色体17p丢失或TP53突变
7. TP53 gene mutation is frequent in patients with acute myeloid leukemia and complex karyotype, and is associated with very poor prognosis [O] . D Bowen, M J Groves, A K Burnett, 2008

机译：TP53基因突变在急性髓性白血病和复杂的核型患者中经常出现，并且与预后非常差有关

TP53 gene mutation is frequent in patients with acute myeloid leukemia and complex karyotype, and is associated with very poor prognosis

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