Symptomatic pericardial effusion in the setting of asymptomatic COVID-19 infection: A case report

摘要

Rationale: Infection with the severe acute respiratory coronavirus disease 2019 ( COVID-19 ) has been shown to cause multi-organ involvement including cardiopulmonary serosal layers infection and inflammation. As a result, pericarditis and pericardial effusion may occur with or without COVID-19 related respiratory signs. Due to limitations in sensitivity and specificity of current COVID-19 diagnostic studies, cases that trigger high clinical intuition, even with negative serologic and polymerase chain reaction testing results, may necessitate further diagnostic workup to discover the underlying etiology. Patient concerns: Here we present a rare case of pericardial effusion in the setting of asymptomatic COVID-19 infection manifesting with the chief complaint of chest pain. Diagnosis: While undergoing diagnostic workup, the patients first 2 sets of COVID 19 reverse transcription-polymerase chain reaction (RT-PCR) were negative while a latter RT-PCR test, as well as serology, were positive, leading to the diagnosis of COVID-19 reinfection or subacute presentation of viral infection with pericardial effusion . Echocardiogram depicted large circumferential pericardial effusion with mildly thickened pericardium. Interventions: The patient underwent pericardial window placement followed by ibuprofen administration and discharged from the hospital. Outcomes: During the follow-up visit patient had no symptoms and echocardiogram demonstrated complete resolution of the effusion. Lessons: Due to the possible establishment of pericardial effusions and consecutively tamponade even without any COVID-19 related clinical presentation, it is crucial for clinicians to trust their intuition, conduct the appropriate diagnostic tests, find the underlying diagnosis and prevent the devastating consequences.