Clinical and imaging features of spinal cord type of neuro Beh?et disease: A case report and systematic review

摘要

Rational: To investigate the clinical and MRI characteristics of spinal cord nerve Beh?et's disease. Patient concerns: One patient with spinal cord nerve Beh?et's disease was admitted to our hospital at October 20, 2015. Diagnose: Spinal cord nerve Beh?et's disease. Interventions: Retrospective analysis was performed on such case as well as 16 cases of spinal cord nerve Beh?et's disease reported in China or abroad. Outcomes: Seventeen cases of spinal cord type of neuro Beh?et's disease include 13 men and 4 women, with an average age of onset of 34.8 years old. The mean time from Beh?et's disease symptoms to spinal cord involvement were 10.8 years. The initial symptom in one case was spinal cord injury, and another 4 cases had a recurrence course. The most common performance of spinal cord injury was sensory disturbance (82.4%), following by weakness (76.5%), sphincter or sexual dysfunction (58.8%), and pain in back, backside of neck or lower chest (29.4%). The number of cells was slightly increased or the protein level was increased in cerebrospinal fluid test. And the water channel protein antibody and oligoclonal band of serum levels were all negative. The spinal cord injury involved more than 3 vertebral bodies in 10 cases, and involved more than half of spinal cord in sagittal plane in 8 cases. In acute stage, shock therapy with large dose of glucocorticoid was generally applied both in China and abroad. Lessons: The clinical features of spinal cord nerve Beh?et's disease were various, making it easily misdiagnosed. Longitudinal extensive transverse myelitis performs as a characteristic manifestation.