Editorial: Molecular Mechanisms of Selective Autophagy in Human Disease

摘要

Autophagy is an essential catabolic process involved in the removal of cytosolic contents throughdouble-membrane vesicles named autophagosomes. Although it has long been considered a bulknon-selective process, it is now clear that autophagy is a highly regulated and specific degradationpathway for the removal of different cellular components. Several forms of selective autophagyhave been characterized, such as: mitophagy, ribophagy, ER-phagy, virophagy, pexophagy,aggrephagy, lipophagy, and glycophagy (Kirkin and Rogov, 2019). Recent studies have revealedan intrinsic connection between selective autophagy and human diseases including infections,neurodegenerative disorders and cancer (Levine and Kroemer, 2019). However, our understandingof the regulation and role of selective-autophagy, in distinct diseases, is still in its infancy. ThisResearch Topic aimed at summarizing recent findings on the involvement of selective types ofautophagy in different human disorders.