EVALUATION OF SERUM KLOTHO LEVEL IN PATIENTS WITH AND WITHOUT CORONARY ARTERY DISEASE

摘要

Background and aims : Serum Klotho is suggested to have protective effect against cardiovascular diseases. Nitric oxide production and preventing of oxidative stress have been suggested as its possible mechanisms of action. In this study we aimed to evaluate the association between serum Klotho level and cardiovascular diseases. Materials and Methods: According to coronary angiography results, 40 patients with normal coronary artery and 40 patients with coronary artery disease included in this study. Serum Klotho level and laboratory data were analyzed for each patient and the association between serum Klotho level and coronary artery disease was evaluated. Results: Our results showed that Serum Klotho level in patients with 1 vessle, 2 vessle and 3 vessel disease was 2.16 ± 0.2, 2.2 ± 0.13, 1.98 ± 0.2 mIU/L respectively. (P value=0.02) The plasma Klotho concentration was significantly lower in patients with coronary artery disease. Discussion : Serum Klotho level can be a useful marker for evaluation of patients with coronary artery disease.