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首页> 外文期刊>Evidence-based complementary and alternative medicine: eCAM >Arsenic Bioaccessibility of Realgar Influenced by the Other Traditional Chinese Medicines in Niuhuang Jiedu Tablet and the Roles of Gut Microbiota
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Arsenic Bioaccessibility of Realgar Influenced by the Other Traditional Chinese Medicines in Niuhuang Jiedu Tablet and the Roles of Gut Microbiota

机译:牛辉·吉富片剂其他中药的砷生物可移植性及肠道微生物的作用

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摘要

Niuhuang Jiedu tablet (NJT), a realgar (As2S2) containing Traditional Chinese Medicine (TCM), is a well-known formula. The safety of NJT is of growing concern since arsenic (As) is considered as one of the most toxic elements. NJT was demonstrated to be safer than realgar by our previous experiments and some other studies. The toxicity of realgar has been shown to be related to the amount of soluble or bioaccessible arsenic. In this study, the influences of the other TCMs in NJT on the bioaccessibility of arsenic from realgar, and the roles of gut microbiota during this process were investigated in vitro. Results showed that Dahuang (Rhei Radix et Rhizoma), Huangqin (Scutellariae Radix), Jiegeng (Platycodonis Radix), and Gancao (Glycyrrhizae Radix et Rhizoma) could significantly reduce the bioaccessibility of arsenic from realgar in artificial gastrointestinal fluids. Gut microbiota played an important role in decreasing the bioaccessibility of realgar because it was demonstrated to be able to absorb the soluble arsenic from realgar in the incubation medium. Dahuang, Huangqin, and Jiegeng could modulate the gut microbiota to enhance its arsenic absorption activity.
机译:Niuhuang Jiedu平板电脑(NJT)是含有中药(TCM)的羊毛(AS2S2),是一种公知的配方。由于砷(AS)被认为是最有毒的元素之一,NJT的安全性越来越受到关注。我们以前的实验和一些其他研究表明,NJT比雄黄更安全。雄黄的毒性已被证明与可溶性或生物可接近砷的量有关。在这项研究中,体外研究了在羊毛中对砷中砷的生物可接受的影响,在该过程中的作用。结果表明,大诚(Rhei adraid et Rhizoma),黄芩(Cocullariae),jiegeng(platycodonis radix)和gancao(glycyrrhizae adtRadix等)可以显着降低人造胃肠流体中砷的生物可接受性。 Gut Microbiota在降低雄黄的生物可接近性方面发挥了重要作用,因为它被证明能够从潜伏培养基中的羊毛吸收可溶性砷。大杭,黄琴和杰格可以调节肠道微生物群,以提高其砷的吸收活动。

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