The expression of OCT4 and its clinical significance in laryngeal squamous carcinoma tissues

摘要

OBJECTIVE: To investigate the expression of OCT4 and its clinical significance in laryngeal squamous carcinoma tissues. PATIENTS AND METHODS: Immunohistochemical staining was used to analyze the expression of OCT4 in 61 cases of laryngeal squamous carcinoma and 10 cases of the adjacent normal laryngeal tissues. RESULTS: The expression of OCT4 was not detected in normal laryngeal tissues, but could be detected in the nucleus of laryngeal carcinoma. The positive expression rates of OCT4 in well-moderately differentiated and poorly differentiated laryngeal squamous carcinoma tissues were 25.6% (11/43) and 66.7% (12/18) respectively, and there were significant differences (p 0.05). CONCLUSIONS: OCT4 is expressed in laryngeal squamous carcinoma tissues and is closely related to the cell differentiation of laryngeal carcinoma, lymph node metastasis and clinical stage.