Long-Term Exposure to Ambient Fine Particulate Matter ([... formula ...]) and Lung Function in Children, Adolescents, and Young Adults: A Longitudinal Cohort Study

摘要

Background: The association between long-term exposure to ambient fine particulate matter with aerodynamic diameter ≤ 2.5 μ m ( PM 2.5 ) and lung function in young people remains uncertain, particularly in Asia, where air pollution is generally a serious problem. Objectives: This study investigated the association between long-term exposure to ambient PM 2.5 and lung function in Taiwanese children, adolescents, and young adults. Methods: This study comprised 24,544 participants 6–24 years of age, with 33,506 medical observations made between 2000 and 2014. We used a spatiotemporal model to estimate PM 2.5 concentrations at participants’ addresses. Spirometry parameters, i.e., forced vital capacity (FVC), forced expiratory volume in 1 s ( FEV 1 ), and maximum midexpiratory flow (MMEF), were determined. A generalized linear mixed model was used to examine the associations between long-term exposure to ambient PM 2.5 and lung function. The odds ratios (ORs) of poor lung function were also calculated after adjusting for a range of covariates. Results: Every 10 - μ g / m 3 increase in the 2-y average PM 2.5 concentration was associated with decreases of 2.22% [95% confidence interval (CI): ? 2.60 , ? 1.85 ], 2.94 (95% CI: ? 3.36 , ? 2.51 ), and 2.79% (95% CI: ? 3.15 , ? 2.41 ) in the FVC, FEV 1 , and MMEF, respectively. Furthermore, it was associated with a 20% increase in the prevalence of poor lung function (OR: 1.20; 95% CI: 1.12, 1.29). Conclusions: Two-year ambient PM 2.5 concentrations were inversely associated with lung function and positively associated with the prevalence of poor lung function in children, adolescents, and young adults in Taiwan.