Activity of Pathomorphologic Changes in Intestinal Lymphoid Tissue Caused by Sharp Intestinal Infections

摘要

Acute intestinal infection is common in children of all ages and takes a special place in infant mortality. Newborns and young children are more susceptible to the development of AII (acute intestinal infection) caused by opportunistic microorganisms if they have primorbid conditions such as premature birth, malnutrition, rickets, anemia and congenital anomalies. In case of artificial and biased vaccination in children, the pathogenic micro florae often causes dysentery, salmonellosis and staphylococcal enterocolit, and other acute intestine infection (AII) [1,2,3]. In the development of AII, especially in a child, an important role is played by general and local factors of the immune system. Several factors play a special role in the local system of protection of the intestinal mucosa, which prevents intestinal infections. Results of morphometric researches showed that babies who died from acute intestinal infections had initially the grown number of stomal cells in lymphoid tissue of both iliac and large intestines of reticular and macrofagal origin with development of destructive changes in them. Parallel with these changes increase of the number of average lymphocytes are noted as the reaction of the immune system of intestines to an infection of active average lymphocytes. In addition to the changes above mentioned, during the subsequent age periods of babies there is growth in the quantity of small lymphocytes in composition of lymphoid follicles, which increases on average in 10-15 times as compared to the norm. Prevalence of acute intestinal infections at children's age and high rates of mortality have caused to consider them as one of actual problems.