Development and Validation of UV Spectrophotometric Method for the Determination of Pazopanib Hydrochloride in Pharmaceutical Dosage Form

摘要

A precise, accurate, simple, cost effective, the ultraviolet spectrophotometric method has been developed for the determination of Pazopanib hydrochloride in the Pharmaceutical dosage form. Pazopanib hydrochloride shows the highest λmax at 273 nm. The Pazopanib hydrochloride follows linearity in the concentration range of 2-10 μg /mL with a decorous correlation coefficient value of 0.999. The precision of the method was studied as an intra-day and inter-day study. The % RSD value is < 2, which indicates that the process is precise. The % recovery was found to be in the range lies between 99.27 - 101.38 %. The percentage assay of Pazopanib hydrochloride (Votrient) obtained was 99.445 %. The Proposed spectrophotometric method was validated as per the ICH Q2 (R1) guidelines. The proposed UV method is accurate, precise and reproducible. Hence this rapid method can be viable for the quality control analysis of Pazopanib hydrochloride in the pharmaceutical dosage form.