FORMULATION AND EVALUATION OF HYDRALAZINE HYDROCHLORIDE BUCCAL FILMS BY SOLVENT CASTING METHOD USING DIFFERENT POLYMERS FOR THE MANAGEMENT OF HYPERTENSION

摘要

The main aim of the study was to formulate the buccal films of most satisfactory formulation by emin-vitro /emevaluation. The present investigation was done to formulate Hydralazine hydrochloride with an objective to improve therapeutic efficacy, Patient compliance. Hydralazine hydrochloride buccal films were developed by solvent casting method. Formulation Hsub2/sub, Psub4/sub, Ssub8/sub, was best fitted to the emin-vitro/em release studies and zero order release was observed.