Immunoproteasome in IgA Nephropathy: State-of-Art and Future Perspectives

摘要

IgA nephropathy (IgAN) is a leading cause of chronic kidney disease and renal failure. The exactpathogenesis of IgAN is not well defined, but some genetic studies have led to a novel discovery that theimmunoproteasome probably plays an important role in IgAN. The immunoproteasome is a proteasomevariant that is expressed when cells are stressed or receive inflammatory signals. Whileimmunoproteasome is suggested to be mainly involved in major histocompatibility complex-I (MHC-I)antigen presentation, recent studies indicate that it may assert broad functions in trafficking events thatactivate both innate and adaptive immunity. In this review, we first summarize new insights into itsfunctions in immunity, and discuss how it underlies its associations with IgAN. We also highlight itspotential as a therapeutic target for the future.