TRPV1 Knockout repairs memory deficits and reduces hippocampal amyloid-β and tau in an Alzheimer's disease mouse model

摘要

Here, we investigated whether TLR2 mediates the propagation of transferred tau proteins using transwell system. We confirmed that cell-to-cell transmission of tau protein in transwell. We found that internalization of transferred tau protein in recipient cell is increased depending on expression level of TLR2. And now, we are testing whether TLR2 antibodies can block the propagation of tau protein.