Dear Editor, Schwannoma or neurilemmoma is a benign tumor of neural origin, uncertain etiology, firstly described in 1910 by Verocay (1910). sup1/sup Schwannomas tend to occur in adults between the third and fifth decades of life and do not show sex predilection. sup2/sup Most of the lesions occur in the head and neck regions (25-40%). sup3/sup However, despite the lips and the oral cavity are highly innervated anatomic sites, they are rarely found in these locations. Only 1% of all schwannomas arise in the oral cavity, being the tongue the most common intraoral site of occurrence. sup4/sup Moreover, schwannomas in the lower lip are excessively rare during childhood and adolescence, with only a few well-documented cases published in the English-language literature. Herein, we presented a rare case of schwannoma in the lower lip mimicking a mucocele in a 7-year-old male child. The patient, a 7-year-old Caucasian male, was referred to the oral medicine service of the School of Dentistry at Tiradentes University, complaining of a painless lesion on the lip over the last 2 months. The extraoral examination was unremarkable. The intraoral examination revealed a fibrous resilient nodular lesion on the left lower lip mucosa, with the coloration resembling normal mucosa, measuring 0.8 cm ( Figure 1 ). Figure 1 Clinical aspect of the lip lesion. Observe the small nodular sessile lesion, with a similar color to the (arrowhead) mucosa in lower lip.: Past medical history was not contributory, except for a local trauma. Based on the clinical aspects, the diagnostic hypothesis was a mucocele. An excisional biopsy was performed, and the specimen was sent for histopathological analysis. Histological examination showed an encapsulated tumor composed of spindle-shaped cells with well-aligned nuclei interpreted as Schwann cells. A palisaded arrangement surrounding central acellular areas, known as Verocay bodies, was observed in most parts, forming a typical Antoni A histological pattern. Less cellular areas comprised of diffusely arranged spindle shaped-cells were also observed, characterizing an Antoni B pattern ( Figure 2A-C ). Immunohistochemical analysis showed a marked positivity of neoplastic cells for S-100 protein ( Figure 2D ). The diagnosis was schwannoma was made. After one year of follow-up, there was no recurrence of the tumor. Figure 2 Photomicrographs of the lip lesion biopsy. A – Well-circumscribed spindle-cell lesion located in the superficial planes (H&E, 2,5X); B – Proliferation of spindle shaped and ovoid cells organized in small fascicles, sometimes forming a palisading arrangement (H&E, 10X); C – detail of neoplastic cells, highlighting well-stained wavy nuclei, with imperceptible nucleoli and Verocay bodies typical of Antoni A pattern (H&E, 20X); D – Immunohistochemical analysis revealing intense and diffuse positivity for S-100 protein (20X).: Swellings of the lower lip can represent many entities, and lip schwannoma is overlooked in the initial differential diagnosis due to its rarity in this location. sup3/sup sup,/sup sup4/sup In our case, the submucosal presentation, slow growth pattern, with no hardening of surround tissues, the clearly defined limits of the tumor, and history of the habit of biting the mucosa reported during the anamnesis suggested a benign process. Therefore, our diagnostic hypothesis included mainly conditions commonly observed in young patients, such as reactive proliferative processes and mesenchymal tumors, and the patient was misdiagnosed with mucocele. Mucocele is a common lesion of the lip, asymptomatic in most cases, similar to the mucosa in color, clinically resembling a variety of other lesions that affect oral soft tissues. sup5/sup Because it is the most common lesion of the lower lip, it would be a dentists’ leading hypothesis as a provisional diagnosis. Thus, histopathological analysis is a necessary procedure to assure the correct diagnosis and therapeutic management. In the oral cavity, the tongue is the most common site affected by schwannoma, and lip tumors are considered rare, with only 21 cases reported in the literature, including the current case. Lip schwannoma tends to occur in adults between the third and fifth decades of life, with a mean age of 26.4 years (range: 7-82) and do not show sex predilection. sup3/sup The diagnosis of schwannoma is based on histological features. Morphologically, schwannoma spindle-shaped cells are arranged in two distinct patterns, Antoni A and B, in variable proportions, with a few or none intralesional axons, forming completely encapsulated lesions. sup5/sup sup,/sup sup6/sup The current case fulfills all the morphological criteria to be classified as schwannoma. It has also been highlighted that immunohistochemical positivity for S
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