Hepcidin and Neutrophil Gelatinase-Associated Lipocalin as a Biomarker for Acute Kidney Injury Linked Iron Metabolism

摘要

Acute kidney injury (AKI) is one of the serious complications of cardiac surgery and can be a significant life-threatening factor associated with high morbidity and mortality [1-3]. There are multiple damaging mechanisms of cardiac surgery-induced AKI, such as ischemia and reperfusion injury, inflammation, and oxidative stress [4]. Among various candidate biomarkers and underlying mechanisms, hepcidin and iron metabolism in AKI are recently attracting the attention of researchers as one of the main mechanisms causing renal damage in various clinical conditions [5-9]. However, the role of iron regulation in cardiac surgery still remains unclear.