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Correction to Remdesivir: A Review of Its Discovery and Development Leading to Human Clinical Trials for Treatment of COVID-19

机译:裁定雷德塞维尔:对其临床试验的发现和发展审查,以治疗Covid-19

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After publication of the original manuscript, we found thatincorrect citations were used in two places in themanuscript in the section Development of Remdesivir. Thecorrect citations with the full references below are as follows:“The study by Warren et al. found that GS-5734 reducedEBOV replication in HeLa cells with an IC50 ≈ 100 nM, and itretained potency in in vivo nonhuman primate EBOV infectionmodels, while GS-441524 was inactive.75,47 In addition todemonstrating activity against EBOV, Agostini et al. showedthat remdesivir also had antiviral activity against several otherviruses, including the coronavirus MERS, with an IC50 of 340nM in vitro.46”.
机译:出版原稿后,我们发现尤为智库在雷德塞维尔的开发部分中使用了两个地方。与下面完整参考的引用的引用如下:“沃伦等人的研究。发现GS-5734在Hela细胞中的GS-5734在具有IC50≈100nm的HeLa细胞中复制,并且在体内非人类灵长类动物EBOV感染表演中的Itretained效力,而GS-441524则在Ebov的令人厌恶的活动中是无活性的。 Showedthtththatthtthat Remdesivir对抗病毒活性对抗几种其他其他病毒,包括冠状病毒MERS,IC50在体外340nm .46“。

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