Oxidative Stress and Human Psoriasis Diseases

摘要

Psoriasis is a chronic inflammatory skin disease characterized by the immune system activation due to genetic and environmental factors that leads to the development of skin lesions. Reactive oxygen species produced as a result of skin inflammation may cause disorders of the antioxidant defense systems and increased oxidative stress in psoriasis which was proposed to have a consequent function in psoriasis. The study was planned to evaluate oxidative stress by measuring Total Oxidant Capacity, Total Anti-oxidant capacity and Oxidative Stress Index in psoriatic patients. Methodology: A comparative cross-sectional study design was used. A total of 90 participants between age of 18-65 years comprising 45 newly diagnosed psoriatic patients and 45 sex and age matched control groups were enrolled in the study. Result: The present study showed significantly increased levels of serum Total Oxidant Capacity (p0.001) as well as Oxidative Stress Index (p0.001) in psoriasis patients as compared to controls and positively correlated with severity and duration of the disease. Total Anti-oxidant capacity levels were significantly (p0.001) lower in patients than in controls and negatively correlated with severity and duration of the disease. Conclusion: These results provide evidences regarding the role of increased reactive oxygen species with decreased antioxidant activity in psoriatic patients.