Effect of Recombinant Human Interleukin-11 on Oral Mucositis Associated with Allogeneic Hematopoietic Stem Cell Transplantation

摘要

Background: Hematopoietic stem cell transplantation gives new life to malignant hematologic patient. However, oral mucositis caused by graft-versus-host disease affects the quality of life of patients. Objective: To observe the efficacy of recombinant human interleuko-11 in the treatment of allogeneic hematopoietic stem cell transplantation associated with oral mucositis. Methods: 54 patients requires an allogeneic hematopoietic stem cell transplantation in patients with hematological clinical observation research, the control group was 0.05% acetic acid chloride solution is folinic acid joint and diluent containing wash, the experimental group on the basis of the join recombinant human interleukin - 11 atomization and contain gargle, comparing curative effect, the ulcer healing time and pain, anxiety and depression scores, as well as oral infections. Results: the efficacy of recombinant human interleukin-11 treatment group was better than that of control group (X~2=4.43; P = 0.035); Nebulized inhalation and gargle containing recombinant human interleuk-11 significantly reduced the mean healing days of oral ulcers (Experimenta group A vs. control group C, P=0.05, P=0.004, P=0.000). Experimental group B vs. control group C, P=0.045, P=0.005, P=0.000) and can reduce the occurrence of pain and bad mood. Conclusion: recombinant human interleukin-11 is effective in the treatment of oral mucositis associated with allogeneic hematopoietic stem cell transplantation. It can effectively shorten the course of disease and reduce the incidence of oral infection, anxiety and depression while reducing the pain of patients.