Protective Effect of Piper nigrum on Sodium Arsenite Induced Toxicity in Charles Foster Rats

摘要

Arsenic in the present times has caused lots of health hazards to humans. In developing countries like Bangladesh and India the high prevalence of contamination, the isolation and poverty of the rural population, and the high cost and complexity of arsenic removal systems have imposed a programmatic and policy challenge on an unprecedented scale. Although in India, arsenic poisoning in ground water in Gangetic belt especially the districts adjoining the river Ganges right from Eastern Uttar Pradesh, Bihar to West Bengal. These regions are the problem of concern as due to which major health related problems are arising. To combat the present problem, a pre-clinical study was carried out on Charles foster rats. They were treated with Sodium arsenite at the dose of 8 mg per kg body weight for 16 weeks to make arsenic model and upon these arsenic pre-treated rats seed extracts of Piper nigrum at the dose of 50 mg per kg body weight was administered for 4 weeks to study the antidote effects of this plant extract. The Piper nigrum extract not only eliminated the effects of arsenic but also reversed the normal physiological activity in the animal by normalising the activity of liver and kidney. The present study concludes that this novel plant extract possesses hepato-protective as well as nephro-protective activity against arsenic induced toxicity.