Immunomodulatory and Anti-angiogenic Properties of Linum usitatissium (flaxseed) Seeds Ethanolic Extract in Atherogenic Diet Treated Rats

摘要

We determined the cardioprotective impact of ethanolic flaxseed seeds extract through an assessment of its immunomodulatory and antiangiogenic characteristics in rats fed with an atherogenic diet. Group 1 fed on the standard diet. Groups 2 and 3 fed on an atherogenic diet (AD) for 12 weeks. Groups 3 and 4 daily supplemented with ethanolic extract of flaxseed seeds (EEFS) 400mg/kg b.w starting from 7th week till the end of 12th week. AD-fed rats had increased serum lipids, CRI-I, CRI-II, cardiac enzymes, and pro-inflammatory markers. Compared to the AD-fed group, EEFS supplementation influenced hypo-lipidemic, anti-inflammatory, anti-angiogenic, and anti-atherogenic characteristics after AD- feeding. EEFS displayed antioxidant capacity in vitro and in vivo. Chromatographic analysis of EEFS demonstrated the presence of phenolic, flavonoid compounds, and vitamin C. The data concludes a safe application of EEFS in atherogenesis-induced cardiac disease management.