Hypoglycemic and Hypolipidemic Effect of Bitter Kola (Garcinia kola) Seed Extract on Alloxan-Induced Diabetic Albino Rats

摘要

The treatment and management of diabetes mellitus has been a challenge to achieve a total cure using conventional drugs. Hypoglycemic and hypolipidemic effects of bitter kola (Garcinia kola) seed extract on alloxan-induced diabetic rats were studied as a local product. Albino rats weighing about 200 g were investigated in groups using 200 - 800 mg/kg weight of bitter kola seed extract and the sample examined for glucose and lipid profiles using enzymatic methods and statistically analyzed using statistical package for social science (SPSS) windows, version 20.0. The results were expressed as the Mean SD. The results for the serum glucose and low density lipoprotein cholesterols (LDL-C) concentrations of untreated diabetic rats, and treated rats showed a significant (P 0.05) progressive decrease from 200 - 800 mg/kg when compared to the control rats. Total cholesterol (TC) and triglycerides (TG) concentrations for untreated diabetic rats, and treated rats showed increase in concentration which was not significant (P 0.05) from 200 - 800 mg/kg weight when compared with the controls. High density lipoproteins (HDL-C) concentrations for untreated diabetic rats, and treated rats showed increase in concentration which was significant (P 0.05) from 200 - 800 mg/kg weight when compared with the controls. This study confirms the hypoglycemic and hypolipidemic effects of bitter kola (Garcinia kola) seed extract.