Synthesis and characterization of 4-((5-bromo-1H-pyrazolo [3,4-b]pyridin-3-yl)amino)-N-(substituted)benzenesulfonamide as Antibacterial, and Antioxidant Candidates

摘要

A series of novel 5-Bromo-3-iodo-1H-pyrazolo[3,4-b]pyridine linked various sulfonamidederivatives 8a-8j poly functionalized were designed and synthesized in moderate to goodyield. A starting with iodination of 5-Bromo-1H-pyrazolo[3,4-b]pyridine 5 with iodineproduced intermediate 5-Bromo-3-iodo-1H-pyrazolo[3,4-b]pyridine 6 with the reaction ofvarious sulfonamide derivatives 7a-7j via copper catalyzed coupling reaction producedtargeted compounds8a-8j. The isolated compounds were accepted by spectral and elementalanalysis. The compounds 8a,8c,8d, and 8i were excellent active against Gram-positive andgram-negative bacterial strain compare to streptomycin standard drug. All synthesizedcompounds showed moderate to good antioxidant properties with used DPPH and Superoxideradical scavenging assay, Compounds 8c, 8g, and 8i exerted significant antioxidant scavengingactivity for the DPPH radical.