Empirical use of antibiotics, a major contributor in hospital Clostridum difficile infection case load. A retrospective study

摘要

The aim of this study was to identify risk factors which lead toClostridium difficile infection (CDI) in patients admitted to hospitaldue to any reason. Methods A retrospective study was conducted looking through the recordsof patients with CDI in a period of 6 months (Aug 2013–Jan 2013)in a district general hospital (DGH) of NHS Wales UK. Thirty-fivepatients were identified who were flagged as CDI positive eitherwith glutamate dehydrogenase toxin or actual organism in thepresence of clinical symptoms. Case-notes and drug-charts wereobtained from medical records and clinical state of the patientin question was investigated at the time of infection. Any historyof antibiotic use during the episode in question or in previous3 months (inpatient or outpatient) was documented. Indicationfor the antibiotics was also identified and whether the indicationwas confirmed prior to that.