Colloidal forming of macroporous calcium pyrophosphate bioceramics in 3D-printed molds

摘要

A technique for colloidal forming of Casub2/subPsub2/subOsub7/sub macroporous bioceramics, based on low-pressure injection molding (LPIM) of a glycerol-water slip containing Casub2/subPsub2/subOsub7/sub and Ca(Нsub2/subPOsub4/sub)sub2/sub into a plastic mold fabricated via FDM 3D-printing, was proposed. Chemical reaction between the solid phases of the water containing slip - Casub2/subPsub2/subOsub7/sub and Ca(Нsub2/subPOsub4/sub)sub2/sub, resulting in brushite (CaHPOsub4/sub·2Hsub2/subO) formation, led to consolidation of the casting and preserved its complex architecture in the course of mold burning-out. Macroporous ceramics of Kelvin structure (70% macropores with the sizes from 2 up to 4?mm), based on a pre-defined composition with 10?wt% Ca(POsub3/sub)sub2/sub and sintered in liquid-phase regime, demonstrated a compressive strength of 1.4?±?0.1?MPa?at a density of 22?±?2%. In vitro tests on bioactivity in SBF solution, as well as on resorption of the ceramics in model solution of citric acid, were carried out.