Factors associated with 24-hour urinary volume: the Swiss salt survey

摘要

Background Low 24-hour urine volume (24UV) may be a significant risk factor for decline in kidney function. We therefore aimed to study associated markers and possible determinants of 24UV in a sample of the Swiss population. Methods The cross-sectional Swiss Salt Study included a population-based sample of 1535 (746 men and 789 women) individuals from three linguistic regions of Switzerland. Data from 1300 subjects were available for the present analysis. 24UV was measured using 24-hour urine collection. Determinants of 24UV were identified using multivariable linear regression models. Results In bivariate analysis, 24UV was higher in women compared to men (2000?ml/24?h [interquartile range (IQR): 1354, 2562] versus 1780?ml/24?h [IQR: 1244, 2360], p?=?0.002). In multivariable regression analyses, independent associated markers of 24UV were female sex (β?=?280, 95% confidence interval [CI]: 174, 386, p? Conclusion In this large population-based, cross-sectional study, we found several strong and independent correlates for 24UV. These findings may be important to improve our understanding in the development of chronic kidney disease.