Inhibition of E-Selectin (GMI-1271) or E-selectin together with CXCR4 (GMI-1359) re-sensitizes multiple myeloma to therapy

Barbara Muz; Feda Azab; Mark Fiala; Justin King; Daniel Kohnen; William E. Fogler; Ted Smith; John L. Magnani; Ravi Vij; Abdel Kareem Azab

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Inhibition of E-Selectin (GMI-1271) or E-selectin together with CXCR4 (GMI-1359) re-sensitizes multiple myeloma to therapy

机译：与CXCR4（GMI-1359）一起抑制E-SELETIN（GMI-1271）或E-SELICIN，将多个骨髓瘤重新敏感到治疗中

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Multiple myeloma (MM) is a plasma cell malignancylocalized in the bone marrow (BM) characterized bycontinuous metastasis. MM remains incurable, despitethe improved overall survival of MM patients due toclinically introduced novel treatments such as proteasomeinhibitors (bortezomib and carfilzomib) and immunomodulatorydrugs (IMiDs; lenalidomide)1.

机译：多发性骨髓瘤（mm）是骨髓（BM）中的血浆细胞，其特征在于颅内转移。毫米仍然是可行的，绝望地改善了MM患者的整体存活，如临床引入的新型治疗，如蛋白酶体inhibitors（Bortezomib和Carfilzomib）和免疫调节器（IMID; Lenalidomide）1。

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《Blood cancer journal.》 |2019年第9期|共页
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Barbara Muz; Feda Azab; Mark Fiala; Justin King; Daniel Kohnen; William E. Fogler; Ted Smith; John L. Magnani; Ravi Vij; Abdel Kareem Azab;
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1. Dual CXCR4 and E-Selectin Inhibitor, GMI-1359, Shows Anti-Bone Metastatic Effects and Synergizes with Docetaxel in Prostate Cancer Cell Intraosseous Growth [J] . Progress in Artificial Intelligence . 2020,第1期

机译：双CXCR4和E-SELETIN抑制剂GMI-1359显示出抗骨转移效果，并在前列腺癌细胞骨内生长中与多西紫杉醇进行促进
2. E-selectin inhibition with GMI-1271 decreases venous thrombosis without profoundly affecting tail vein bleeding in a mouse model [J] . Culmer Dorian L., Dunbar Misha L., Hawley Angela E., Thrombosis and Haemostasis: Journal of the International Society on Thrombosis and Haemostasis . 2017,第6期

机译：通过GMI-1271 e-Selectin抑制减少静脉血栓形成，而不会深入地影响小鼠模型中的尾静脉血
3. Sialyltransferase inhibition leads to inhibition of tumor cell interactions with E-selectin, VCAM1, and MADCAM1, and improves survival in a human multiple myeloma mouse model [J] . Alessandro Natoni, Mariah L. Farrell, Sophie Harris, Haematologica . 2020,第2期

机译：Sialyl转移酶抑制导致抑制肿瘤细胞与e-Selectin，Vcam1和Madcam1的相互作用，并改善人类多发性骨髓瘤小鼠模型中的存活
4. Inhibition of E-Selectin by Selectively deSulfated Heparin through Chitosan Microspheres Impregnated Collagen Scaffold [C] . T.S. Ramyaa Lakshmi, N. Shanmugasundaram, Mary Babu World congress on medical physics and biomedical engineering;International congress of the IUPESM . 2011

机译：通过壳聚糖微球浸渍胶原蛋白支架选择性脱硫肝素对E-选择素的抑制作用
5. Normal and malignant lymphocyte migration: Glycosyltransferases and integrins in lymphocyte homing and CXCR4 inhibition of multiple myeloma. [D] . Gauguet, Jean-Marc. 2005

机译：正常和恶性淋巴细胞迁移：淋巴细胞归巢中的糖基转移酶和整联蛋白和多发性骨髓瘤的CXCR4抑制。
6. Inhibition of E-Selectin (GMI-1271) or E-selectin together with CXCR4 (GMI-1359) re-sensitizes multiple myeloma to therapy [O] . Barbara Muz, Feda Azab, Mark Fiala, 2019

机译：抑制E-选择素（GMI-1271）或E-选择素与CXCR4（GMI-1359）一起可使多发性骨髓瘤对治疗敏感
7. Inhibition of E-Selectin (GMI-1271) or E-selectin together with CXCR4 (GMI-1359) re-sensitizes multiple myeloma to therapy [O] . Barbara Muz, Feda Azab, Mark Fiala, 2019

机译：与CXCR4（GMI-1359）一起抑制E-SELETIN（GMI-1271）或E-SELICIN，将多个骨髓瘤重新敏感到治疗中

Inhibition of E-Selectin (GMI-1271) or E-selectin together with CXCR4 (GMI-1359) re-sensitizes multiple myeloma to therapy

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