Mechanochemically synthesized mesoporous alumina: a smart new‑generation sorbent for preparation of chromatographic _(188)W/_(188)Re generator

摘要

In an effort towards affordable availability of chromatographic ~(188)W/~(188)Re generators for widespread clinical use, wereport the mechanochemical synthesis of mesoporous alumina as an advanced sorbent material for preparation of thegenerator. The synthesized material exhibits remarkably high sorption capacity (550 ± 12 mg W/g), which is adequatefor preparation of clinical-scale generators using low specific activity (LSA) ~(188)W produced in medium flux research reactors.Sorption of ~(188)W in mesoporous alumina follows Freundlich adsorption isotherm and pseudo second order kinetics,indicating that the process is chemisorption. A clinical-scale (～ 14.0 GBq) ~(188)W/~（188）Re generator was developed and itsperformance was evaluated over a period of 6 months. Rhenium-188 could be consistently obtained from the generatorwith high yield (> 80%) and it met all the requirements for clinical use. The present strategy is expected to increase thescope of separation chemistry for availing clinical-grade ~(188)Re for the benefit of millions of cancer patients world over.