Supercoiling DNA (folding DNA into a more compact molecule) from open circular forms requires significant bending energy. The double helix is coiled into a higher order helix form; thus it occupies a smaller footprint. Compact packing of DNA is essential to improve the efficiency of gene delivery, which has broad implications in biology and pharmaceutical research. Here we show that low-intensity pulsed ultrasound can pack open circular DNA into supercoil form. Plasmid DNA subjected to 5.4 mW/cm2 intensity ultrasound showed significant (p-values
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机译：来自开放圆形形式的超螺旋DNA（将DNA折叠成更紧密的分子）需要大量的弯曲能量。双螺旋盘绕成更高阶的螺旋形式。因此，它占用的空间较小。 DNA的紧凑包装对于提高基因传递的效率至关重要，这在生物学和药物研究中具有广泛的意义。在这里，我们证明了低强度脉冲超声可以将开放的环状DNA包装成超螺旋形式。接受5.4 mW / cm 2 强度超声的质粒DNA显示出显着的（p值
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