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外文期刊>Journal of bacteriology
>Suppressor Scanning at Positions 177 and 236 in the Escherichia coli Lactose/H+ Cotransporter and Stereotypical Effects of Acidic Substituents That Suggest a Favored Orientation of Transmembrane Segments Relative to the Lipid Bilayer
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Suppressor Scanning at Positions 177 and 236 in the Escherichia coli Lactose/H+ Cotransporter and Stereotypical Effects of Acidic Substituents That Suggest a Favored Orientation of Transmembrane Segments Relative to the Lipid Bilayer
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机译:大肠杆菌乳糖/ H +共转运蛋白第177位和236位的抑制子扫描以及酸性取代基的定型效应,表明相对于脂质双分子层跨膜节段的定向性好
Acidic substituents for Ala-177 (helix 6) or Tyr-236 (helix 7) in LacY cause effects on sugar recognition and cosubstrate coupling that are stereotypical of neutral substituents. Thus, helices 6 and 7 are probably oriented to produce little side-chain contact with the low dielectric lipid bilayer at positions 177 and 236.
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