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美国卫生研究院文献>Journal of Bacteriology
>Note: Suppressor Scanning at Positions 177 and 236 in the Escherichia coli Lactose/H+ Cotransporter and Stereotypical Effects of Acidic Substituents That Suggest a Favored Orientation of Transmembrane Segments Relative to the Lipid Bilayer
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Note: Suppressor Scanning at Positions 177 and 236 in the Escherichia coli Lactose/H+ Cotransporter and Stereotypical Effects of Acidic Substituents That Suggest a Favored Orientation of Transmembrane Segments Relative to the Lipid Bilayer
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机译：注意：在大肠杆菌乳糖/ H +共转运蛋白的177和236位置进行抑制子扫描以及酸性取代基的定型效应表明脂质膜的跨膜链段取向有利
Acidic substituents for Ala-177 (helix 6) or Tyr-236 (helix 7) in LacY cause effects on sugar recognition and cosubstrate coupling that are stereotypical of neutral substituents. Thus, helices 6 and 7 are probably oriented to produce little side-chain contact with the low dielectric lipid bilayer at positions 177 and 236.
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