...
首页> 外文期刊>Journal of Clinical and Diagnostic Research >Topical Diltiazem is Superior to Topical Lignocaine in the Treatment of Chronic Anal Fissure: Results of A Prospective Comparative Study
【24h】

Topical Diltiazem is Superior to Topical Lignocaine in the Treatment of Chronic Anal Fissure: Results of A Prospective Comparative Study

机译:外用地尔硫卓在局部治疗慢性肛裂方面优于外用利格卡因:一项前瞻性比较研究的结果

获取原文
   

获取外文期刊封面封底 >>

       

摘要

Introduction: Fissure in ano is a troubling and painful condition that affects a great majority of the population the world over. Chronic anal fissures are associated with persistent hypertonia and spasm of the internal anal sphincter and they have conventionally been treated surgically. However, concerns have been raised about the risk of faecal incontinence after surgical sphicterotomy. In this study, we have explored topical 2% diltiazem as an effective and a safe alternative method to surgical treatment. Materials and methods: In this prospective comparative study, 200 patients with chronic anal fissure from a single centre were included. They were randomly divided into the test group and the control group, with 100 patients in each group. The test group was instructed to apply 2% topical diltiazem ointment and control group was instructed to apply topical 2% Lignocaine twice daily for 6 consecutive weeks. They were asked to apply the medicine just inside the anal canal and 1cm around the anus circumferentially. The assessment was done at the 2nd, 4th and the 6th weekends for fissure healing, pain relief, bleeding control, control of discharge/perianal itching and for the side effects of the medicines. Results: Complete healing of the fissure was observed in 72% of the patients in the test group against 23% in the control group by the end of 6 weeks (P< 0.0001). The pain relief was also good as the pain score in the test group dropped from 80 (mean) to 5 (mean) over the 6 weeks time. 80% of the test group cases experienced absent bleeding by the end of the 6th week as compared to 42% in the control group (P<0.001). 90% of the subjects in the test group reported a significant reduction in the discharge and the perianal pruritis as compared to 50 % in the control group (P<0.0001). 3 patients had a mild headache, while 10 patients experienced slight perianal pruritis. In the 1 year follow up, 4.28% subjects in the test group reported recurrence of the symptoms against 34.78% in the control group. Conclusion: We conclude that 2% topical diltiazem is quite effective in the treatment of chronic fissure in ano.Statistical analysis used: Chi square and P-value (SPSS software version 17).
机译:简介:ano的裂痕是一种令人痛苦和痛苦的状况,影响着全世界绝大多数人口。慢性肛裂与持续的高渗和肛门内括约肌痉挛有关,常规上已通过手术治疗。然而,人们已经对手术括约肌切开术后粪便失禁的风险提出了担忧。在这项研究中,我们探索了局部2%地尔硫卓是一种有效且安全的替代手术治疗方法。材料和方法:在这项前瞻性比较研究中,纳入了来自单个中心的200例慢性肛裂患者。他们被随机分为测试组和对照组,每组100名患者。指示测试组使用2%局部用地尔硫卓软膏,指示对照组连续2周每天使用2%的利多卡因局部用药。他们被要求在肛管内和肛门周围1cm处涂抹药物。评估在第二,第四和第六个周末进行,以治疗裂痕愈合,缓解疼痛,控制出血,控制出院/肛周瘙痒以及药物的副作用。结果:到6周结束时,在测试组中72%的患者观察到裂隙完全愈合,而在对照组中则为23%(P <0.0001)。疼痛缓解效果也很好,因为测试组的疼痛评分在6周内从80(平均)下降到5(平均)。到第6周末,有80%的测试组病例没有出血,而对照组只有42%(P <0.001)。与对照组的50%相比,测试组中90%的受试者报告出院和肛周瘙痒明显减少(P <0.0001)。 3例轻度头痛,而10例轻度肛周炎。在1年的随访中,测试组中4.28%的受试者报告了症状的复发,而对照组为34.78%。结论:我们得出结论,局部用地尔硫卓2%可以有效治疗慢性裂痕。使用的统计分析:卡方和P值(SPSS软件版本17)。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号