Role of Interleukin-33 in Immunity and Periodontal Inflammation-A Literature Review

摘要

The Interleukin-33 (IL-33) is a member of IL-1 family discovered in the year of 2005. The Interleukin-1 (IL-1) family of cytokines iscommonly encountered in chronic in?ammatory diseases such as rheumatoid arthritis and periodontitis. IL-33 regulates the innateand adaptive immunity and it also participates in initiation and progression of periodontal diseases. The aim of this review was toanalyse the biological and immunological role of IL-33 in progression of periodontal diseases. This review also deals with the IL-33signaling pathway in the periodontal in?ammation.