A Comparison Of Nifedipine With Methyldopa For Control Of Blood Pressure In Mild To Moderate Pregnancy Induced Hypertension.

摘要

Objectives: To compare efficacy of nifedipine and methyldopa for control of blood pressure in mild to moderate pregnancy induced hypertension (PIH).Methods: A comparative study of efficacy of nifedipine and methyl dopa was carried out in 50 pregnant women with pregnancy induced hypertension. Patients were randomly selected who were on either oral nifedipine or oral methyl dopa on a standard dose and blood pressure was measured at 0, 6, 24, 48 and 72 hours of initiation of therapy. Adverse and side effects of drugs were also recorded during this treatment period. Control of blood pressure was assessed in each treatment group by statistical analysis using one way ANOVA followed by Dunnett?s test. P values <0.05 were considered as significant. Results: The result showed both nifedipine and methyl dopa were equally effective in control of blood pressure. Both treatments were well tolerated with minimal side effects. Conclusion: Data analysis of the study shows both nifedipine and methyl dopa are equally effective in reducing the blood pressure in pregnancy induced hypertension, nifedipine may be preferred in view of low cost and easy availability.