Oxidative Stress And Ascorbic Acid Levels In Cavitary Pulmonary Tuberculosis

摘要

Abstract: Oxidative stress is implicated in the pathogenesis of many diseases. It has been evidenced by various studies that free radicals are involved in the progression of pulmonary tuberculosis and also, in the damage caused to the lung tissue.Aim: The present study was conducted to assess the severity of oxidative stress (MDA) and the levels of antioxidants (vitamin C) in advanced (cavitary) pulmonary tuberculosis by comparing it with the non cavitary cases. Methodology: 50 cases and 30 controls were included in this study. The cases were further divided into cavitary and non-cavitary on the basis of the chest X-ray reports. The levels of lipid peroxidation (MDA) were estimated by the method of Stocks and Dormandy and those of vitamin C were estimated by the method of Varley. Result: The levels of lipid peroxidation increased significantly in the cavitary cases and also, the levels of the antioxidants (vitamin C) were found to be decreased significantly in the cavitary cases as compared to the non-cavitary cases. Conclusion: Oxidative stress was found to be increased highly significantly in cavitary pulmonary tuberculosis. The levels of the antioxidants (vitamin C) decreased highly significantly with an increase in lipid peroxidation levels.