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首页> 外文期刊>Journal of Clinical Microbiology >Positive Correlation between Epstein-Barr Virus Viral Load and Anti-Viral Capsid Immunoglobulin G Titers Determined for Hodgkin's Lymphoma Patients and Their Relatives
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Positive Correlation between Epstein-Barr Virus Viral Load and Anti-Viral Capsid Immunoglobulin G Titers Determined for Hodgkin's Lymphoma Patients and Their Relatives

机译:确定何杰金氏淋巴瘤患者及其亲属的爱泼斯坦-巴尔病毒病毒载量和抗病毒衣壳免疫球蛋白G滴度之间的正相关

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Markers of Epstein-Barr virus (EBV) infection include measures of specific serological titers and of viral load (VLo) in peripheral blood mononuclear cells. Few studies have investigated the correlation between these two phenotypes. Here, we found that there was no correlation between VLo and either anti-EBV nuclear antigen type 1 or anti-early antigen immunoglobulin G (IgG) titer but that anti-viral capsid antigen (VCA) IgG titer increased with VLo in peripheral blood mononuclear cells in patients with Hodgkin's lymphoma (P = 3.10?3). A similar pattern was observed in healthy first-degree relatives (parents and siblings) of patients (P = 6.10?4). Our results indicate that anti-VCA IgG titers and EBV VLo are specifically correlated EBV phenotypes.
机译:爱泼斯坦-巴尔病毒(EBV)感染的标志物包括外周血单核细胞中特定血清学滴度和病毒载量(VLo)的量度。很少有研究调查这两个表型之间的相关性。在这里,我们发现VLo与1型抗EBV核抗原或抗早期抗原免疫球蛋白G(IgG)滴度之间没有相关性,但是外周血单核中的抗病毒衣壳抗原(VCA)IgG滴度随VLo升高霍奇金淋巴瘤患者的细胞( P = 3.10 ?3 )。在患者的健康一级亲属(父母和兄弟姐妹)中观察到了类似的模式( P = 6.10 ?4 )。我们的结果表明,抗VCA IgG滴度和EBV VLo是特异相关的EBV表型。

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