机译：构成内部核包膜的核层状延伸蛋白网络。该网络包括class =“ underline”> L AP2- class =“ underline”> e merin- class =“ underline”> M AN1- class =“ underline “> d omain（LEM-d）proteinfamily，proteinsthatshareanassociationwiththechromatinbindingproteinBarrier到autointegrationfactor（BAF）.LossofindividualLEM-Dproteinscausesprogressive，组织restricteddiseases，knownaslaminopathies.Mechanismsassociatedwithlaminopathiesarenotyetunderstood.HerewepresentourstudiesofoneoftheDrosophilanuclearlaminaLEM-Dproteins，Otefin（OTE），ahomologueofemerin.PreviousstudieshaveshownthatOteisautonomouslyrequiredforthesurvivaloffemalegermlinestemcells（GSC中证明我们还需要Oteis来维持卵巢小生境中的体细胞存活，但由于细胞数量的减少和信号转导的改变而导致Ote的损失。我们展示了限制细胞表达的结果，揭示了Oteinniche的自主功能。 SCscontributetothemaintenanceoftheirownniches.Further，weinvestigatetherequirementofOteinthemalefertility.Weshowthat OTE mutantmalesbecomeprematurelysterileastheyage.Paralleltoobservationsinfemales，thissterilityisassociatedwithGSClossandchangesinsomaticcellsoftheniche，phenotypesthatarelargelyrescuedbygermcell-restrictedOteexpression.Takentogether，ourstudiesdemonstratethatOteisrequiredautonomouslyforsurvivaloftwostemcellpopulations，aswellasnon-autonomouslyformaintenanceoftwosomaticniches.Finally，ourdataaddtogrowingevidencethatLEM-Dproteinshavecriticalrolesinstemcellsurvivalandtissuehomeostasis。
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