Sox8 is a critical regulator of adult Sertoli cell function and male fertility

Moira K. OBryan; Shuji Takada; Claire L. Kennedy; Greg Scott; Shun-ichi Harada; Manas K. Ray; Qunsheng Dai; Dagmar Wilhelm; David M. de Kretser; E. Mitch Eddy; Peter Koopman; Yuji Mishina

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Sox8 is a critical regulator of adult Sertoli cell function and male fertility

机译：Sox8是成人Sertoli细胞功能和男性生育能力的关键调节剂

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emSox8/emencodesahigh-mobilitygrouptranscriptionfactorthatiswidelyexpressedduringdevelopment.emSox8/em,-em9/emand-em10/emformgroupEoftheemSox/emgenefamilywhichhasbeenimplicatedinseveralhumandevelopmentaldisorders.IncontrasttootheremSoxE/emgenes,theroleofemSox8/emisunclearandemSox8/emmousemutantsreportedlyshowedonlyidiopathicweightlossandreducedbonedensity.ThecarefulanalysisofouremSox8/emnullmice,however,revealedaprogressivemaleinfertilityphenotype.emSox8/emnullmalesonlysporadicallyproducedlittersofreducedsizeatyoungages.WehaveshownthatSOX8proteinisaproductofadultSertolicellsanditseliminationresultsinanage-dependentderegulationofspermatogenesis,characterizedbysloughingofspermatocytesandroundspermatids,spermiationfailureandaprogressivedisorganizationofthespermatogeniccycle,whichresultedintheinappropriateplacementandjuxtapositionofgermcelltypeswithintheepithelium.Thosespermthatdidentertheepididymidesdisplayedabnormalmotility.ThesedatashowthatSOX8isacriticalregulatorofadultSertolicellfunctionandisrequiredforbothitscytoarchitecturalandparacrineinteractionswithgermcells./p/div

机译： Sox8 编码在发展过程中广泛表达的高迁移率族转录因子。 Sox8 ，- 9 和- 10 formgroup与其他 SoxE 基因相反， Sox8 的病因尚不清楚，并且 Sox8 小鼠突变体据报道仅具有特发性体重减轻和降低的骨密度。 SOX8 nullmalesonlysporadicallyproducedlittersofreducedsizeatyoungages.WehaveshownthatSOX8proteinisaproductofadultSertolicellsanditseliminationresultsinanage-dependentderegulationofspermatogenesis，characterizedbysloughingofspermatocytesandroundspermatids，spermiationfailureandaprogressivedisorganizationofthespermatogeniccycle，whichresultedintheinappropriateplacementandjuxtapositionofgermcelltypeswithintheepithelium.Thosespermthatdidentertheepididymidesdisplayedabnormalmotility.ThesedatashowthatSOX8isa 展开▼

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《Developmental biology》 |2008年第2期|共页

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Moira K. OBryan; Shuji Takada; Claire L. Kennedy; Greg Scott; Shun-ichi Harada; Manas K. Ray; Qunsheng Dai; Dagmar Wilhelm; David M. de Kretser; E. Mitch Eddy; Peter Koopman; Yuji Mishina;
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中图分类生物科学;

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1. Sox8 is a critical regulator of adult Sertoli cell function and male fertility. [J] . OBryan MK, Takada S, Kennedy CL Developmental biology . 2008,第2期

机译：Sox8是成人Sertoli细胞功能和男性生育能力的关键调节剂。

2. GATA4 regulates Sertoli cell function and fertility in adult male mice. [J] . Kyronlahti A, Euler R, Bielinska M, Molecular and Cellular Endocrinology . 2011,第1期

机译：GATA4调节成年雄性小鼠的支持细胞功能和繁殖力。

3. SOX8 regulates permeability of the blood-testes barrier that affects adult male fertility in the mouse [J] . Biology of Reproduction: Offical Journal of the Society for the Study of Reproduction . 2013,第5期

机译：SOX8调节血液-睾丸屏障的通透性，影响小鼠成年男性的生育能力

4. The Effect of Vitamin C, Vitamin E, Glutation and Zink Combination on the Number of Sertoli and Leydig Cells. Pre-Clinical Test in Male Wistar Rats (Rattus Norvegicus) Exposed to Cigarette Smoke [C] . Conita Yuniarifa, Joko Wahyu Wibowo, Taufiqurrachman Nasihun International Conference on Bioinformatics and Nanomedicine from Natural Resources for Biomedical Research . 2019

机译：维生素C，维生素E，谷胱甘肽和锌组合对Sertoli和Leydig细胞数的影响。雄性Wistar大鼠（Rattus Norvegicus）暴露于香烟烟雾的临床前试验

5. Progerin expression disrupts critical adult stem cell functions that mediate tissue repair primarily through a mechanism that permanently farnesylates lamin A [D] . Pacheco, Laurin Marie 2015

机译：早搏素的表达破坏了主要通过介导层粘连蛋白A的法呢基化机制介导组织修复的关键成人干细胞功能。

6. Sox8 is a critical regulator of adult Sertoli cell function and male fertility [O] . Moira K. OBryan, Shuji Takada, Claire L. Kennedy, -1

机译：Sox8是成人Sertoli细胞功能和男性生育能力的关键调节剂

7. Sox8 is a critical regulator of adult Sertoli cell function and male fertility [O] . OBryan Moira K., Takada Shuji, Kennedy Claire L., 2008

机译：Sox8是成人Sertoli细胞功能和男性生育能力的关键调节剂

1. 激素及其受体调节Sertoli细胞功能的研究进展 [J] . 曾毓琪 ,张小莉 ,朱可喻 . 国际生殖健康/计划生育杂志 . 2019,第005期

2. 睾丸Sertoli细胞功能研究的新进展 [J] . 严俨 ,赵冉 ,徐奕玫 . 中国男科学杂志 . 2016,第001期

3. RNA干扰PPT1基因表达对小鼠Sertoli细胞功能的影响 [J] . 周婉格 ,周任 ,王统菲 . 中国男科学杂志 . 2014,第004期

4. 不同葡萄糖浓度对大鼠睾丸Sertoli细胞功能的影响 [J] . 廖波 ,邓显忠 ,姜果 . 实用医学杂志 . 2013,第002期

5. 猪Sertoli细胞在异种移植模型中对人免疫细胞功能的影响 [J] . 谢林 ,尹注增 ,胡枫 . 华中科技大学学报（医学版） . 2008,第006期

6. 成人隐匿性自身免疫性糖尿病患者血清IL-10、TGF-β水平及其与胰岛β细胞功能的关系 [C] . 范右飞 ,王静 ,杨松 . 第七次全国中西医结合中青年学术研讨会暨福建中西医结合研究院2009年学术年会 . 2009

7. T3干预Flutamide诱导SD鼠生精上皮Connexin43表达及Sertoli细胞功能成熟的研究 [A] . 赵丹 . 2010

1. Rheb1作为β细胞功能障碍的关键调节因子的应用 [P] . 中国专利： CN113577282A . 2021-11-02

2. Grb10作为β细胞功能障碍的关键负调节因子中的应用 [P] . 中国专利： CN111494635A . 2020-08-07

3. Nucleotide sequence (seq-id no-2) rna molecule plasmid vector DNA cell plant cell process of mediating plant fertility process of mediating male plant fertility with intermediate male fertility process to provide externally inherited male sterility in process plant to reproduce male plant control sterile process of producing hybrid seed and cassette express [P] . 外国专利： BR9408621A . 1998-07-21

机译：核苷酸序列（seq-id no-2）rna分子载体DNA细胞植物细胞介导植物育性的过程介导雄性植物育性与中度雄性育性过程的过程，为加工植物提供外部遗传的雄性不育，以繁殖雄性植物控制的不育过程种子和盒式杂种快车的生产

4. nucleic acid molecule, polypeptide, chimeric gene, plant cell, plant, plant part, or seed, methods for producing a cereal plant or plant cell or seed thereof or for enhancing the restorative capacity for g-type cytoplasmic male sterility of wheat, to convert a non-restorative cereal plant into a restorative plant for wheat type g cytoplasmic male sterility or to enhance the restorative capacity for wheat type g cytoplasmic male sterility, to select or produce a cereal plant and to produce seed hybrid, to restore fertility in a progeny or to produce a fertile progeny plant, to identify and / or select a cereal plant, and to determine the presence or absence or zygosity state of a functional restorer gene allele, and, uses of acid nucleic acid, at least one marker and one plant [P] . 外国专利： BR112019000886A2 . 2019-04-30

机译：核酸分子，多肽，嵌合基因，植物细胞，植物，植物部分或种子，生产谷类植物或植物细胞或其种子或增强小麦的g型细胞质雄性不育恢复能力的方法将非恢复性谷物植物转变为小麦g型细胞质雄性不育的恢复性植物，或增强小麦g型细胞质雄性不育的恢复性能力，以选择或生产谷物植物并产生种子杂种，以恢复子代的育性或产生可育的子代植物，鉴定和/或选择谷类植物，确定功能性恢复基因等位基因的存在与否或合子状态，以及酸性核酸，至少一种标记物和一种植物的用途

5. ADULT BONE MARROW CELL TRANSPLANTATION TO TESTES CREATION OF TRANSDIFFERENTIATED TESTES GERM CELLS, LEYDIG CELLS AND SERTOLI CELLS [P] . 外国专利： US2015258149A1 . 2015-09-17

机译：成人骨髓细胞移植以测试转分化的测试细胞的生长，生殖细胞，莱迪格细胞和睾丸支持细胞

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Sox8 is a critical regulator of adult Sertoli cell function and male fertility

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