The C. elegans M3 neuron guides the growth cone of its sister cell M2 via the Kr&uuml;ppel-like zinc finger protein MNM-2

Manish Rauthan; Catarina Mouml; rck; Marc Pilon

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The C. elegans M3 neuron guides the growth cone of its sister cell M2 via the Krüppel-like zinc finger protein MNM-2

机译：秀丽隐杆线虫M3神经元通过类似Krppel锌指蛋白MNM-2引导其姊妹细胞M2的生长锥

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Theinvariantcellndash;cellinteractionsoccurringduringemC.elegans/emdevelopmentofferuniqueopportunitiestodiscoverhowgrowingaxonsmayreceiveguidancecuesfromneighboringcells.Theemmnm-2/emmutantwasisolatedbecauseofitsdefectsintheaxontrajectoryofthebilateralM2pharyngealneuronsinemC.elegans/em.Wefoundthatemmnm-2/emenhancestheeffectsofmanygrowthconeguidancemutationsontheseaxons,suggestingthatitperformsanovelfunctionduringaxonguidance.Weclonedemmnm-2/emandfoundthatitencodesaproteinwiththreeC2H2zincfingerdomainsrelatedtotheKruuml;ppel-likeFactorproteinfamily.emmnm-2/emisexpressedonlytransientlyintheM2neuron,butexhibitsasustainedexpressioninitssistercell,theM3neuron.Strikingly,theexpressionofemmnm-2/emisnotsustainedintheM3celloftheemmnm-2/emmutant,indicatingthatthisgenepositivelyregulatesitselfinthatcell.ElectropharyngeogramsalsoindicatethattheM3cellisfunctionallyimpairedintheemmnm-2/emmutant.WeusedanM3-specificpromotertoshowthattheM2axondefectcanberescuedbyexpressionofemmnm-2/eminitssistercellM3.Thesamepromoterwasusedtoexpressthepro-apoptoticgeneemegl-1/emtokilltheM3cell,whichresultedinanM2axonguidancedefectsimilartothatfoundintheemmnm-2/emmutant.OurresultssuggestanM2axonguidancemodelinwhichtheM3cellprovidesanimportantsignaltothegrowthconeofitssisterM2andthatthissignalandtheproperdifferentiationofM3bothdependonemmnm-2/emexpression.Thismechanismofaxonguidanceregulationallowsfine-tuningoftrajectoriesbetweensistercells./p/div

机译：Theinvariantcellndash; cellinteractionsoccurringduring <位置>线虫的developmentofferuniqueopportunitiestodiscoverhowgrowingaxonsmayreceiveguidancecuesfromneighboringcells.The <位置> MNM-2 的mutantwasisolatedbecauseofitsdefectsintheaxontrajectoryofthebilateralM2pharyngealneuronsin <位置>线虫的.Wefoundthat <位置> MNM-2 的enhancestheeffectsofmanygrowthconeguidancemutationsontheseaxons ，suggestingthatitperformsanovelfunctionduringaxonguidance.Wecloned <位置> MNM-2 的andfoundthatitencodesaproteinwiththreeC2H2zincfingerdomainsrelatedtotheKruuml ;. ppel-likeFactorproteinfamily <位置> MNM-2 的isexpressedonlytransientlyintheM2neuron，butexhibitsasustainedexpressioninitssistercell，theM3neuron.Strikingly，theexpressionof <位置> MNM-2 的isnotsustainedintheM3cellofthe mnm-2 突变体，表明该基因正向调节该细胞本身。人体电生理曲线图还表明M3细胞在 mnm-2 突变体中具有功能性。我们使用M3特异性启动子来表明该M2轴缺陷得以消除。 ressionof <位置> MNM-2 的initssistercellM3.Thesamepromoterwasusedtoexpressthepro-apoptoticgene <位置> EGL-1 的tokilltheM3cell，whichresultedinanM2axonguidancedefectsimilartothatfoundinthe <位置> MNM-2 的mutant.OurresultssuggestanM2axonguidancemodelinwhichtheM3cellprovidesanimportantsignaltothegrowthconeofitssisterM2andthatthissignalandtheproperdifferentiationofM3bothdependon <位置> MNM-2 展开▼

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《Developmental biology》 |2007年第1期|共页

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Manish Rauthan; Catarina Mouml; rck; Marc Pilon;
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1. The C-elegans M3 neuron guides the growth cone of its sister cell M2 via the Kruppel-like zinc finger protein MNM-2 [J] . Rauthan M, Morck C, Pilon M Developmental biology . 2007,第1期

机译：C-线虫M3神经元通过类似Kruppel的锌指蛋白MNM-2引导其姊妹细胞M2的生长锥

2. Early Developmental Expression of Mus musculus Zinc Finger RNA-Binding Protein Compared to Orthologs in Caenorhabditis elegans and Danio rerio and Subcellular Localization of Mus musculus and Caenorhabditis elegans Zinc Finger RNA-Binding Protein in 2-Cell Mus musculus Embryos [J] . Doganli, Canan, Kjaergaard, Tine, Olsen, Anders, DNA and Cell Biology . 2010,第12期

机译：与线粒体和线粒体直向同源物相比，小家鼠锌指RNA结合蛋白的早期发育表达以及2细胞小家鼠胚胎中小家鼠和秀丽线虫锌指RNA结合蛋白的亚细胞定位

3. The zinc finger protein REF-2 functions with the Hox genes to inhibit cell fusion in the ventral epidermis of C. elegans. [J] . Alper S, Kenyon C Development . 2002,第14期

机译：锌指蛋白REF-2与Hox基因一起起作用，以抑制秀丽隐杆线虫腹侧表皮中的细胞融合。

4. Modulation of C. elegans transcription factor activity by HIM-8 and the related zinc finger ZIM proteins. [D] . Sun, Hongliu. 2008

机译：HIM-8和相关锌指ZIM蛋白对秀丽隐杆线虫转录因子活性的调节。

5. Zinc fingers in sex determination: only one of the two C. elegans Tra-1 proteins binds DNA in vitro. [O] . D Zarkower, J Hodgkin 1993

机译：锌指在性别鉴定中的作用：两种秀丽隐杆线虫Tra-1蛋白中只有一种在体外与DNA结合。

6. The C. elegans M3 neuron guides the growth cone of its sister cell M2 via the Krüppel-like zinc finger protein MNM-2 [O] . Rauthan Manish, Mörck Catarina, Pilon Marc 2007

机译：秀丽隐杆线虫M3神经元通过类似克鲁勃氏锌指蛋白MNM-2引导其姊妹细胞M2的生长锥

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The C. elegans M3 neuron guides the growth cone of its sister cell M2 via the Kr&uuml;ppel-like zinc finger protein MNM-2

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The C. elegans M3 neuron guides the growth cone of its sister cell M2 via the Krüppel-like zinc finger protein MNM-2