The bHLH transcription factor Ascl1a is essential for the specification of the intestinal secretory cells and mediates Notch signaling in the zebrafish intestine

Lydie C. Flasse; David G. Stern; Justine L. Pirson; Isabelle Manfroid; Bernard Peers; Marianne L. Voz

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The bHLH transcription factor Ascl1a is essential for the specification of the intestinal secretory cells and mediates Notch signaling in the zebrafish intestine

机译：bHLH转录因子Ascl1a对于规范肠道分泌细胞至关重要，并介导斑马鱼肠道中的Notch信号传导

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Notchsignalinghasafundamentalroleinstemcellmaintenanceandincellfatechoiceintheintestineofdifferentspecies.Canonically,Notchsignalingrepressestheexpressionoftranscriptionfactorsoftheemachaete-scute/emlike(ASCL)orematonal/emrelatedprotein(ARP)families.IdentifyingtheARP/ASCLgenesexpressedinthegastrointestinaltractisessentialtobuildtheregulatorycascadecontrollingthedifferentiationofgastrointestinalprogenitorsintothedifferentintestinalcelltypes.TheexpressionoftheARP/ASCLfactorswasanalyzedinzebrafishtoidentify,amongalltheARP/ASCLfactorsfoundinthezebrafishgenome,thoseexpressedinthegastrointestinaltract.emascl1a/emwasfoundtobetheearliestfactordetectedintheintestine.Loss-of-functionanalysesusingtheempia/ascl1a/emmutant,revealedthatemascl1a/emiscrucialforthedifferentiationofallsecretorycells.Furthermore,weidentifyabatteryoftranscriptionfactorsexpressedduringsecretorycelldifferentiationanddownstreamofemascl1a/em.Finally,weshowthattherepressionofsecretorycellfatebyNotchsignalingismediatedbytheinhibitionofemascl1a/emexpression.Inconclusion,thisworkidentifiesAscl1aasakeyregulatorofthesecretorycelllineageinthezebrafishintestine,playingthesameroleasAtoh1inthemouseintestine.ThishighlightsthediversityintheARP/ASCLfamilymembersactingascellfatedeterminantsdownstreamfromNotchsignaling./p/div

机译：Notchsignalinghasafundamentalroleinstemcellmaintenanceandincellfatechoiceintheintestineofdifferentspecies.Canonically，Notchsignalingrepressestheexpressionoftranscriptionfactorsofthe achaete-盾像（ASCL）或无调 relatedprotein（ARP）families.IdentifyingtheARP / ASCLgenesexpressedinthegastrointestinaltractisessentialtobuildtheregulatorycascadecontrollingthedifferentiationofgastrointestinalprogenitorsintothedifferentintestinalcelltypes.TheexpressionoftheARP / ASCLfactorswasanalyzedinzebrafishtoidentify，amongalltheARP / ASCLfactorsfoundinthezebrafishgenome，thoseexpressedinthegastrointestinaltract。 ascl1a 被发现是在肠道中检测到的最早的因素。使用 pia / ascl1a 突变体进行的功能丧失分析表明， ascl1a 对于分泌下降的分泌细胞是至关重要的。此外，我们经常发现我们显示出Notchsign对分泌细胞命运的抑制总之，这项工作可以识别斑马鱼肠道分泌细胞系的Ascl1aasa调节因子，并在小鼠肠道中扮演沙门氏菌atoh1。这突显了ARP / ASCL突变确定的多样性。 展开▼

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《Developmental biology》 |2013年第2期|共页

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Lydie C. Flasse; David G. Stern; Justine L. Pirson; Isabelle Manfroid; Bernard Peers; Marianne L. Voz;
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1. The bHLH transcription factor Ascl1a is essential for the specification of the intestinal secretory cells and mediates Notch signaling in the zebrafish intestine [J] . FlasseL.C., SternD.G., PirsonJ.L., Developmental biology . 2013,第2期

机译：bHLH转录因子Ascl1a对于规范肠道分泌细胞至关重要，并介导斑马鱼肠道中的Notch信号传导

2. The bHLH factors Dpn and members of the E(spl) complex mediate the function of Notch signalling regulating cell proliferation during wing disc development The bHLH factors Dpn and members of the E(spl) complex mediate the function of Notch signalling regulating cell proliferation during wing disc development The bHLH factors Dpn and members of the E(spl) complex mediate the function of Notch signalling regulating cell proliferation during wing disc development [J] . Antonio Baonza, Beatriz P. San Juan, Irene Andrade-Zapata Biology Open . 2012,第7期

机译：bHLH因子Dpn和E（spl）复合物的成员介导Notch信号调节机翼盘发育过程中细胞增殖的功能bHLH因子Dpn和E（spl）复合物的成员介导Notch信号调节机翼发育过程中细胞增殖的功能椎间盘的发育bHLH因子Dpn和E（spl）复合物的成员介导Notch信号调节机翼椎间盘发育过程中细胞增殖的功能

3. A nonclassical bHLH Rbpj transcription factor complex is required for specification of GABAergic neurons independent of Notch signaling. [J] . Hori K, Cholewa-Waclaw J, Nakada Y, Genes and Development: a Journal Devoted to the Molecular Analysis of Gene Expression in Eukaryotes, Prokaryotes, and Viruses . 2008,第2期

机译：非经典的bHLH Rbpj转录因子复合体是独立于Notch信号指定GABA能神经元所必需的。

4. Disruption of Cell-Cell Contact-mediated Notch Signaling via Hydrogel Encapsulation Reduces Mesenchymal Stem Cell Chondrogenic Potential [C] . Amanda X. Chen, Michael D. Hoffman, Caressa S. Chen, Society for Biomaterials annual meeting and exposition . 2015

机译：通过水凝胶封装的细胞间接触介导的Notch信号的破坏减少间充质干细胞软骨形成电位。

5. Control of the Notch Signaling Pathway in Mammary Gland Development and Carcinogenesis by the Stem Cell Specific Transcription Factor DeltaNp63. [D] . Kent, Sierra Shane. 2012

机译：干细胞特异性转录因子DeltaNp63对乳腺发育和癌变过程中Notch信号通路的控制。

6. A nonclassical bHLH–Rbpj transcription factor complex is required for specification of GABAergic neurons independent of Notch signaling [O] . Kei Hori, Justyna Cholewa-Waclaw, Yuji Nakada, 2008

机译：非经典的bHLH–Rbpj转录因子复合体是独立于Notch信号的GABA能神经元规格所必需的

7. The bHLH transcription factor Ascl1a is essential for the specification of the intestinal secretory cells and mediates Notch signaling in the zebrafish intestine. [O] . Flasse, Lydie C., Stern, David, Pirson, Justine, 2013

机译：bHLH转录因子Ascl1a对于规范肠道分泌细胞至关重要，并在斑马鱼肠道中介导Notch信号传导。

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The bHLH transcription factor Ascl1a is essential for the specification of the intestinal secretory cells and mediates Notch signaling in the zebrafish intestine

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