Mnb/Dyrk1A Is Transiently Expressed and Asymmetrically Segregated in Neural Progenitor Cells at the Transition to Neurogenic Divisions

B. Hauml; mmerle; E. Vera-Samper; S. Speicher; R. Arencibia; S. Mart??nez; F.J. Tejedor

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Mnb/Dyrk1A Is Transiently Expressed and Asymmetrically Segregated in Neural Progenitor Cells at the Transition to Neurogenic Divisions

机译：Mnb / Dyrk1A过渡表达和神经元分裂的神经祖细胞中的瞬时表达和不对称隔离。

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TheemMinibrain/em(emMnb/em)geneencodesanewfamilyofproteinkinasesthatisevolutionarilyconservedfrominsectstohumans.InemDrosophila/em,emMnb/emisinvolvedinpostembryonicneurogenesis.Inhumans,emMNB/emhasbeenmappedwithintheDown'sSyndrome(DS)criticalregionofchromosome21andisoverexpressedinDSembryonicbrain.InordertostudyapossibleroleofemMnb/emontheneurogenesisofvertebratebrain,wehaveclonedthechickemMnb/emorthologueandstudiedthespatiotemporalexpressionofemMnb/eminproliferativeregionsofthenervoussystem.Inearlyembryos,emMnb/emisexpressedbeforetheonsetofneurogenesisinthethreegenerallocationswhereneuronalprecursorsareoriginated:neuroepitheliaoftheneuraltube,neuralcrest,andcranialplacodes.emMnb/emistransientlyexpressedduringasinglecellcycleofneuroepithelialprogenitor(NEP)cells.emMnb/emexpressionprecedesandwidelyoverlapswiththeexpressionofTis21,anantiproliferativegenethathasbeenreportedtobeexpressedintheonsetofneurogenicdivisionsofNEPcells.emMnb/emtranscriptionbeginsinmitosis,continuesduringGsub1/sub,andstopsbeforeS-phase.Veryinterestingly,wehavefoundthatemMnb/emmRNAisasymmetricallylocalizedduringthemitosisofthesecellsandinheritedbyoneofthesiblingcellsafterdivision.WeproposethatemMnb/emdefinesatransitionstepbetweenproliferatingandneurogenicdivisionsofNEPcells./p/div

机译：小脑（ Mnb ）基因编码一个从昆虫到人类进化进化保守的新的蛋白激酶家族。在果蝇中， Mnb 与胚胎后神经发生有关。 > hasbeenmappedwithintheDown'sSyndrome（DS）criticalregionofchromosome21andisoverexpressedinDSembryonicbrain.Inordertostudyapossibleroleof MNB ontheneurogenesisofvertebratebrain，wehaveclonedthechick MNB orthologueandstudiedthespatiotemporalexpressionof MNB inproliferativeregionsofthenervoussystem.Inearlyembryos， MNB isexpressedbeforetheonsetofneurogenesisinthethreegenerallocationswhereneuronalprecursorsareoriginated：neuroepitheliaoftheneuraltube，神经脊，andcranialplacodes <位置> MNB 的istransientlyexpressedduringasinglecellcycleofneuroepithelialprogenitor（NEP）细胞<位置> MNB 的expressionprecedesandwidelyoverlapswiththeexpressionofTis21，anantiproliferativegenethathasbeenreportedtobeexpressedintheonsetofneurogenicdivisionsofNEPcells <位置> MNB 的创见...裂隙开始有丝分裂，持续到G _{1 ，并在S期之前停止。非常有趣的是，我们发现 Mnb 在这些细胞的有丝分裂过程中对称地局部定位，并由同胞和继发性继承法继承} 展开▼

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《Developmental biology》 |2002年第2期|共页

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B. Hauml; mmerle; E. Vera-Samper; S. Speicher; R. Arencibia; S. Mart??nez; F.J. Tejedor;
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1. Mnb/Dyrk1A is transiently expressed and asymmetrically segregated in neural progenitor cells at the transition to neurogenic divisions [J] . Hammerle B., Vera-Samper E., Speicher S., Developmental biology . 2002,第2期

机译：Mnb / Dyrk1A在过渡到神经源性分裂时在神经祖细胞中瞬时表达和不对称分离

2. Mnb/Dyrk1A is transiently expressed and asymmetrically segregated in neural progenitor cells at the transition to neurogenic divisions [J] . Hammerle B., Vera-Samper E., Speicher S., Developmental biology . 2002,第2期

机译：Mnb / Dyrk1A在过渡到神经源性分裂时在神经祖细胞中瞬时表达和不对称分离

3. Mnb/Dyrk1A orchestrates a transcriptional network at the transition from self-renewing neurogenic progenitors to postmitotic neuronal precursors [J] . Shaikh Mirja N., Tejedor Francisco J. Journal of neurogenetics . 2018,第1a4期

机译：MNB / Dyrk1a在从自我更新神经源性祖细胞到后关染的神经元前体的转型中调节转录网络

4. Transient Expression of Neurogenin-2 through Nanoparticles Enhances Neuronal Differentiation of Human Embryonic Stem Cell-Derived Neural Progenitors [C] . Xiaowei Li, Markus Tammia, Yongjuan Ren, Society for biomaterials annual meeting and exposition . 2013

机译：Neurogenin-2通过纳米粒子的瞬时表达增强了人类胚胎干细胞衍生的神经祖细胞的神经元分化。

5. A study of human homologs of selected Drosophila genes in human mammary ductal carcinoma, asymmetric cell division of human neural stem cells and a multiplex microsphere bead assay for comparative RNA expression analysis. [D] . Fuja, Tannin J. 2003

机译：对人类乳腺导管癌中所选果蝇基因的人类同源物，人类神经干细胞的不对称细胞分裂以及用于比较RNA表达分析的多重微球珠分析的研究。

6. Transient expression of Mnb/Dyrk1a couples cell cycle exit and differentiation of neuronal precursors by inducing p27KIP1 expression and suppressing NOTCH signaling [O] . Barbara Hämmerle, Edgar Ulin, Jordi Guimera, -1

机译：Mnb / Dyrk1a的瞬时表达通过诱导p27KIP1表达和抑制NOTCH信号传导使细胞周期退出和神经元前体分化相结合。

7. Mnb/Dyrk1A Is Transiently Expressed and Asymmetrically Segregated in Neural Progenitor Cells at the Transition to Neurogenic Divisions [O] . Hämmerle B., Vera-Samper E., Speicher S., 2002

机译：Mnb / Dyrk1A在过渡到神经性分裂的神经祖细胞中瞬时表达和不对称分离。

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Mnb/Dyrk1A Is Transiently Expressed and Asymmetrically Segregated in Neural Progenitor Cells at the Transition to Neurogenic Divisions

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